Low dose aspirin,platelet function and prostaglandin synthesis: Influence of epinephrine and alpha adrenergic blockade |
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| Affiliation: | 1. University of Minnesota Health Sciences Center, Department of Laboratory Medicine Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA;1. University of Minnesota Health Sciences Center, Department Pathology, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA;2. University of Minnesota Health Sciences Center, Department Pediatrics, Box 198 Mayo Memorial Building, Minneapolis, Minnesota 55455 USA;1. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664 , Poland;2. Faculty of Chemistry, University of Opole, Oleska 48, Opole 45-052 , Poland;1. Institute of Biomedical Engineering, Bogazici University, 34684 Istanbul, Turkey;2. Department of Chemistry, Faculty of Arts and Sciences, Suleyman Demirel University, 32260 Isparta, Turkey;3. Department of Chemistry, Faculty of Sciences, Hacettepe University, 06800 Ankara, Turkey;4. Department of Physics, Faculty of Arts and Sciences, Suleyman Demirel University, 32260 Isparta, Turkey;1. Institute for Molecules and Materials, Department of Synthetic Organic Chemistry, Radboud University Nijmegen, Nijmegen, the Netherlands;2. Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;3. Hubrecht Institute, Utrecht, the Netherlands;1. Centre for Metabolomics and Bioanalysis (CEMBIO), Faculty of Pharmacy, Universidad San Pablo CEU, CEU Universities. Campus Monteprincipe, Boadilla Del Monte, 28668, Madrid, Spain;2. Department of Biopharmaceutics and Pharmacodynamics, Faculty of Pharmacy, Medical University of Gdańsk, Poland;1. School of Nano Sciences, Central University of Gujarat, Gandhinagar 382030, India;2. School of Life Sciences, Central University of Gujarat, Gandhinagar 382030, India;3. School of Pharmacy, National Forensic Sciences University, Gandhinagar 382007, Gujarat, India |
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| Abstract: | The present investigation has evaluated the effects of low doses of oral aspirin on platelet prostaglandin synthesis and function. Whole (80 mg) or half (40 mg) tablets of baby aspirin given to adults had no effect on the response of their platelets to thrombin, ADP and epinephrine, but selectively inhibited aggregation induced by threshold concentrations of arachidonate 16–20 hours after ingestion. Larger amounts of arachidonate overcame the inhibition imposed by low dose aspirin, but not by adult aspirin tablets (600 mg). Epinephrine, in concentrations too low to cause aggregation, restored the sensitivity of aspirin-treated platelets to arachidonate. Studies with a-adrenergic agonists, antagonists and calcium channel blockers demonstrated that the corrective effect of epinephrine was mediated by an a-adrenergic receptor influence on calcium modulation of the platelet membrane. |
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