Embryopathic effects of thromboxane B2 in the chick |
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| Affiliation: | 1. Department of Anatomy, College of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, N.J. 07103, U.S.A.;2. Department of Anatomy, University of Manitoba, 730 William Avenue, Winnipeg, Canada, R3E OW3;1. National Pilot School of Software, Yunnan University, Kunming, 650091, Yunnan, China;2. Yunnan Key Laboratory of Software Engineering, China;3. School of Information Science, Yunnan University, Kunming, 650091, Yunnan, China;1. Center for Structural Pharmacology and Therapeutics Development, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China;2. Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China;3. Department of Biophysics and Department of Pathology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China;4. Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China;5. Liangzhu Laboratory, Zhejiang University, Hangzhou 311121, China;6. Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China;7. Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China;8. MOE Frontier Science Center for Brain Research and Brain-Machine Integration, Zhejiang University School of Medicine, Hangzhou 310058, China;1. Department of Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan;2. Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Kyoto 606-8507, Japan;3. Laboratory of Ultrastructural Virology, Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Kyoto 606-8507, Japan;4. Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka 573-1010, Japan;5. RIKEN Spring-8 Center, Life Science Research Infrastructure Group, Sayo-gun, Hyogo 679-5148, Japan |
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| Abstract: | Several prostaglandins of the E and F series are now known to be involved in reproduction and developmental events. However, there is as yet no such evidence for any of the other arachidonate metabolites. Thromboxane B2 is the stable metabolic end product of the biologically active but unstable intermediate thromboxane A. Administered to developing chick embryos at 48 and 72 hours incubation, thromboxane B2 caused growth retardation and induced a high incidence of anomalies, in particular,everted viscera. |
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