Influence of prostaglandins on vasoconstrictor responses in the hindquarters vascular bed of the cat |
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| Affiliation: | 1. School of Chemical Engineering, Iran University of Science and Technology, Narmak, Tehran 16846-13114, Iran;2. Fuel Cell Laboratory, Green Research Center, Iran University of Science and Technology, Narmak, Tehran, Iran;1. Unit of Dermatology, DMU3ID, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France;2. Department of Dermatology, Saint-Louis Hospital, AP-HP, Institut National de la Santé et de la Recherche Médicale U976, Université de Paris Paris, France;3. Department of Dermatology, Henri Mondor Hospital, AP-HP, Paris-Est Créteil Val de Marne–Paris 12 University, Créteil, France;4. Department of Dermatology, Cochin Hospital, AP-HP, Paris Descartes University, Paris, France;5. Department of Dermatology, Edouard Herriot Hospital, Lyon, France;6. Department of Parasitology-Mycology, Saint-Louis Hospital, AP-HP, Université de Paris Paris, France;7. Unit of Molecular Mycology, Centre National de la Recherche Scientifique Unité Mixte de Recherche 2000, Institut Pasteur, Paris, France;8. Unit of Public Health, Department of Biostatistics, Pitié-Salpêtrière Hospital, AP-HP, Sorbonne University, Paris, France;9. Department of Pathology, Tenon Hospital, AP-HP, Paris, France;10. Department of Dermatology, Amiens University Hospital, Amiens, France;11. Department of Dermatology, Grenoble University Hospital, Grenoble, France;12. Department of Pathology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France;13. Department of Dermatology, DMU3ID, Tenon Hospital, AP-HP, Paris, France;1. Centre for Blood Research, 2350 Health Sciences Mall, University of British Columbia, Vancouver V6T 1Z3, Canada;2. Department of Pathology and Laboratory of Medicine, Room G227-2211 Westbrook Mall, University of British Columbia, Vancouver V6T 2B5, Canada;3. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 45000, China;4. Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver V6T 1Z1, Canada;1. Department of Pharmacy, University of Naples Federico II, Naples, Italy;2. Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, United Kingdom;3. Drug Discovery and Development, Italian Institute of Technology, Genoa, Italy;4. Science of Health Department, School of Medicine, University “Magna Graecia” of Catanzaro, Catanzaro, Italy |
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| Abstract: | The effects of prostaglandins (PG) A1, A2, B2, E1, E2, 6-keto-E1, F2α and indomethacin on vascular resistance and vasoconstrictor responses were investigated in the feline hindquarters vascular bed under conditions of controlled flow so that changes in perfusion pressure directly reflect changes in vascular resistance. Infusion of PGE1 , PGE2 and 6-keto-PGE1 (3 μg/min) into the abdominal aorta significantly dilated the hindquarters vascular bed and inhibited vasoconstrictor responses to sympathetic nerve stimulation and intra-arterial injections of angiotensin, whereas hindquarters vasoconstrictor responses to tyramine and exogenous norepinephrine were unaffected. Infusion of PGA1, A2, B2 and F2α at a similar rate produced transient changes in hindquarters vascular resistance and did not consistently alter vasoconstrictor responses to sympathetic nerve stimulation, angiotensin, norepinephrine and tyramine. Indomethacin in a dose which greatly attenuates the response to intravenous administration of arachidonic acid enhanced responses to nerve stimulation and norepinephrine. In addition, indomethacin had little or no effect on hindquarters perfusion pressure and systemic arterial pressure. These data suggest that E series prostaglandins possess the ability to modulate the actions of the sympathetic nervous system and angiotensin in the feline hindquarters vascular bed. In addition, these data suggest that PGEs, upon enzymatic conversion and dehydration to A and B series prostaglandins, lose their ability to consistently affect vasoconstrictor responses. Experiments with indomethacin further suggest that locally formed prostaglandins do modulate the effects of the sympathetic nervous system of the feline hindquarters. |
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