Increased frequency of sister-chromatid exchanges in alcoholics |
| |
| Affiliation: | 1. Instituto de Investigaciones Sociales, Universidad Nacional Autónoma de México, Circuito Mario de la Cueva, Ciudad Universitaria, Coyoacán, 04510 Ciudad de México, Mexico;2. Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Autónoma de México - Campus Morelia, Antigua Carretera a Pátzcuaro, Col. Exhacienda de San José Huerta, C.P. 58190, Morelia, Michoacán, Mexico;1. Center for Nonlinear Science, Department of Physics, University of North Texas, 1155 Union Circle, #311427, Denton, TX 76203-5017, USA;2. Department of Electrical and Computer Engineering, University of Manitoba, 75A Chancellor''s Circle, Winnipeg, MBR3T 5V6, Canada;3. Department of Mathematics, AdıyamanUniversity, 02040 Adıyaman, Turkey;4. Department of Mathematics, Faculty of Arts and Sciences, AdıyamanUniversity, 02040 Adıyaman, Turkey;5. Computational Intelligence Laboratory, University of Manitoba, WPG, MB, R3T 5V6, Canada;6. BM-Science – Brain and Mind Technologies Research Centre, Espoo, Finland;7. Dept. Psychology and Dept. Engineering, Northeastern University, Boston, MA, USA;8. Peter the Great Polytechnic University, St. Petersburg, Russia;1. Department of Cardiovascular, Endocrine-Metabolic and Ageing-Associated Diseases, Istituto Superiore di Sanità, Rome, Italy;2. Department of Medical and Clinical Sciences, University of Bologna, Bologna, Italy;3. Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy;4. Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy;5. Non-Invasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation, Rome, Italy |
| |
| Abstract: | The frequency of SCEs was significantly increased in the alcoholics analyzed (10.6 ± SD 0.66) when compared to the frequency of a control group (8.4 ± SD 0.51). Statistical analysis of the data obtained showed that the increase was not apparently related to age, sex cigarette smoking, duration in years of alcohol abuse, nutritional status or type of alcoholic beverage commonly consumed by the individual.Alcoholics recovering for at least one year from alcohol abuse were examined and the frequency of SCEs was found to be equal to the SCE frequency in the control group.There was no statistical significance between the age, sex of the individual, smoking history and years of abstention from alcohol abuse with respect to the frequency of SCEs. Therefore, one year of abstention appears sufficient to allow the SCE frequency to return to that found in the control group.In order to keep extraneous factors at a minimum and to analyze the effect of a particular factor, such as alcohol, on the number of SCEs, a careful medical history and screening program was followed. However, more information is needed to determine which factors play a role in causing genetic damage and inducing SCEs and to determine the significance SCEs may have with respect to genetic information and function. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
