Coexistence of renin and cathepsin B in epithelioid cell secretory granules |
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| Authors: | R. Taugner C. P. Bührle R. Nobiling H. Kirschke |
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| Affiliation: | (1) I. Physiologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 326, D-6900 Heidelberg, Germany;(2) Physiologisch-Chemisches Institut, Martin Luther-Universität, Hollystrasse 1, P.O. Box 184, Halle (Saale), Germany |
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| Abstract: | Summary Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin B-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin B is suggested to be involved in the activation of renin prior to secretion.These studies were supported by the German Research Foundation within the SFB 90  Cardiovasculäres System |
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