Combined transport of water and ions through membrane channels |
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Authors: | Pohl Peter |
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Affiliation: | Forschungsinstitut für Molekulare Pharmakologie, Robert-R?ssle-Str. 10, D-13125 Berlin, Germany. pohl@fmp-berlin.de |
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Abstract: | The coupling of ion and water flow through membrane channels is under dispute. Among all human aquaporins only aquaporin-6 exhibits ion channel activity. Whether aquaporin-6 functions also as a water channel cannot yet be determined with confidence. Similarly, a comparison of single-channel water permeabilities from ion channels and aquaporins suggests that ion channels may play a secondary role as water channels. However, the fraction of absorbed fluid that crosses epithelial ion channels still remains to be determined. |
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