The assessment of trabecular bone parameters and cortical bone strength: A comparison of micro-CT and dental cone-beam CT |
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Authors: | Jui-Ting Hsu Shun-Ping Wang Heng-Li Huang Ying-Ju Chen Jay Wu Ming-Tzu Tsai |
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Institution: | 1. School of Dentistry, College of Medicine, China Medical University, Taichung 404, Taiwan;2. Department of Orthopaedics, Taichung Veterans General Hospital, Taichung 407, Taiwan;3. Stem Cell Medical Research Center, Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan;4. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 404, Taiwan;5. Department of Biomedical Engineering, Hungkuang University, Taichung 433, Taiwan |
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Abstract: | This study compared the capabilities of micro-computed tomography (micro-CT) and dental cone-beam computed tomography (CBCT) in assessing trabecular bone parameters and cortical bone strength. Micro-CT and CBCT scans were applied to 28 femurs from 14 rats to obtain independent measurements of the volumetric cancellous bone mineral density (vCanBMD) in the femoral head, volumetric cortical bone mineral density (vCtBMD) in the femoral diaphysis, cross-sectional moment of inertia (CSMI), and bone strength index (BSI) (=CSMI×vCtBMD). Five structural parameters of the trabecular bone of the femoral head were calculated from micro-CT images. A three-point bending test was then conducted to measure the fracture load of each femur. Bivariate linear Pearson analysis was conducted to calculate the correlation coefficients (r values) of the micro-CT, dental CBCT, and three-point bending measurements. The statistical analyses showed a strong correlation between vCanBMD values obtained using micro-CT and dental CBCT (r=0.830). There were strong or moderate correlation between vCanBMD measured using dental CBCT and five parameters of trabecular structure measured using micro-CT. Additionally, the results were satisfactory regardless of whether micro-CT or dental CBCT was used to measure the femoral diaphysis vCtBMD (r=0.733 and 0.680, respectively), CSMI (r=0.756 and 0.726, respectively), or BSI (r=0.846 and 0.847, respectively) to predict fracture loads. This study has yielded a new method for using dental CBCT to evaluate bone parameters and bone strength; however, further studies are necessary to validate the use of dental CBCT on humans. |
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Keywords: | Dental cone-beam computed tomography (dental CBCT) Micro-computed tomography (micro-CT) Bone mineral density (BMD) Trabecular bone structural parameter Three-point bending Cortical bone strength Rat femur |
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