| L-NNA对猫眼球运动神经元突触后诱发电位的影响 |
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| 作者姓名： | Li QJ Li WB Zeng JB Wang HG |
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| 作者单位： | 河北医科大学基础医学研究所病理生理学研究室,石家庄,050017 |
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| 基金项目： | 河北省自然科学基金!资助项目 (No 3942 97) |
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| 摘 要： | 本研究探讨内源性一氧化氮(NO)对猫中脑·间脑结合部Forel′sfieldH(FFH)区神经元与下斜肌(inferioroblique,IO)眼球运动神经元(oculomotoneurons,OMNs)之间兴奋性突触传递的影响。首先电刺激FFH内侧区,在IOOMNs池内诱发兴奋性单突触电场电位,然后观察颈动脉注入NO合酶抑制剂N硝基L精氨酸(LNNA)后这一电位的变化。结果表明,应用LNNA后2～3min,这一突触后电位的振幅开始逐渐减小,6～10min时减小至最低水平,而后缓慢恢复。预先给予NO前体L精氨酸(LArg)可抵消LNNA的上述效应,但LArg本身并不引起这一电位出现变化。这些结果提示:生理情况下,动眼神经核内存在着NO的基础释放,NO对FFH神经元与OMNs之间的突触传递过程具有促进作用
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| 关 键 词： | 一氧化氮 突触传递 FFH OMNs 电位 兴奋 |
Effects of L-NNA on postsynaptically evoked potential of oculomotoneurons in cats |
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| Li QJ,Li WB,Zeng JB,Wang HG.Effects of L-NNA on postsynaptically evoked potential of oculomotoneurons in cats[J].Acta Physiologica Sinica,1999,0(6):623-629. |
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| Authors: | Li Q J Li W B Zeng J B Wang H G |
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| Institution: | Department of Pathophysiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017. |
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| Abstract: | The present study was performed to explore the effect of endogenous nitric oxide (NO) on synaptic transmission between neurons located in Forel's field H (FFH) and vertical oculomotoneurons (OMNs) innervating the inferior oblique (IO) muscle in cats. The amplitude of monosynaptic excitatory field potential in the IO OMNs pool induced by stimulating FFH began to decrease gradually 2-3 min after intracarotid administration of L-NNA, an NO synthase inhibitor, reached its minimum by 6-10 min, and was followed by a slow recovery. This effect of L-NNA could be prevented by pre-administration of NO precursor L-arginine, without changing the field potential by itself. The results suggest that there is an endogenous NO release in the oculomotor nuclear, which can potentiate synaptic transmission between FFH neurons and OMNs. |
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