肠道菌群与腹泻型肠易激综合征 相关性的研究进展

肠易激综合征(IBS)是一种常见的功能性胃肠道疾病,其特征是反复发作的腹痛,伴随排便频率与大便性状的改变。腹泻为主的肠易激综合征(IBS-D)是其主要亚型,主要表现是腹痛和腹泻。目前IBS-D的发病机制尚不完全明确,但大量的研究提示可能与胃肠道动力紊乱、黏膜通透性和肠上皮屏障功能改变、内脏高敏感性增加、"脑-肠-菌"轴失调、肠道感染与炎症反应激活、精神心理因素异常等有关。随着研究的不断深入,发现肠道菌群与IBS-D的关系密切,调节肠道菌群的益生菌干预成为缓解IBS-D相关症状的手段之一。本研究就近十余年来肠道菌群情况与IBS-D关系的研究现状作一综述。

The progress of the relationship between intestinal microbiota and diarrhea-predominant irritable bowel syndrome

Abstract: Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders. It is characterized by recurrent abdominal pain, and changes in the frequency and shape of stool. Diarrhea-predominant irritable bowel syndrome (IBS-D) is its main subtype, its clinical manifestations are abdominal pain and diarrhea. The pathogenesis of IBS-D is not fully clear up to now, but numerous studies suggest that it is related to multiple factors, such as abnormal gastrointestinal motility, altered mucosal permeability and intestinal epithelial barrier function, increased visceral hypersensitivity, unbalanced brain-gut-enteric microbiota axis, intestinal infection and inflammation, abnormal psychological factors. The dysbiosis of the gastrointestinal tract microbiota is considered one of the most important factors responsible for the development of IBS-D, and taking probiotics has been one of the means to relieve the symptoms of IBS-D by regulating intestinal microbiota. In this article, we will discuss the relationship between intestinal microbiota and IBS-D in recent years.