炎症性肠病患者Th22细胞亚群和IL-22水平变化及其临床意义

目的 探讨Th22细胞亚群和血清白介素-22（IL-22）水平在炎症性肠病（IBD）患者中的变化及其临床意义。 方法 选取2016年1月至2018年4月我院收治的125例IBD患者作为研究对象，其中克罗恩病（CD）组患者65例，溃疡性结肠炎（UC）组患者60例。选取同期进行体检的健康者50例作为对照组。比较各组对象Th22细胞亚群，血清IL-22、C-反应蛋白(CRP)、红细胞沉降率（ESR）水平，并进行相关性分析。 结果 CD组和UC组患者Th22细胞比例及IL-22、CRP、ESR水平均显著高于对照组（均P结论 Th22细胞亚群和IL-22水平与IBD患者病情严重程度关系密切，提示Th22细胞亚群和IL-22可能参与IBD发病过程中的炎症过程。

Changes and clinical significance of levels of Th22 cell subsets and IL-22 in patients with inflammatory bowel disease

Objective To explore the changes and significance of levels of Th22 cell subsets and serum Interleukin-22 (IL-22) in inflammatory bowel disease (IBD) Methods A total of 125 patients with IBD in our hospital from January 2016 to April 2018 were selected, including 65 cases of Crohn′s disease (CD group) and 60 cases of Ulcerative colitis (UC group) 50 healthy persons were selected as the control group The subsets of Th22 cells and the levels of serum IL-22, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in each group were compared and the correlation was analyzed Results Compared with control group, the percentage of Th22 cells and the level of IL-22 in CD group and UC group were significantly higher respectively (all PConclusion The subsets of Th22 cells and the level of IL-22 are closely related to the severity of IBD, suggesting that they may be involved in the inflammatory process of IBD