细菌性阴道病合并人乳头瘤病毒感染的 影响因素

目的分析细菌性阴道病(BV)合并人乳头瘤病毒(HPV)感染的影响因素,为预防BV合并HPV感染的发生提供参考依据。方法收集2017年2月至2017年12月就诊于天津中医药大学第一附属医院符合标准的妇女,观察组为HPV合并BV感染的患者,对照组为健康妇女,通过问卷调查研究两组妇女一般情况的差异性。结果共纳入204名研究对象,其中观察组78例,对照组126例。观察组中HPV感染以单型感染居多,共46例,占59.0%;观察组以高危型别感染居多,共70例,占89.7%。通过单因素回归分析可得年龄≥40岁(P=0.000,OR=3.795)、初次性生活年龄20岁(P=0.011,OR=2.914)、性伴侣数≥2(P=0.036,OR=2.005)、每周性生活次数2次(P=0.029,OR=1.927)、妊娠次数≥2(P=0.000,OR=2.920)是导致HPV合并BV感染的影响因素。多因素非条件logistic回归分析结果显示年龄≥40岁(P=0.001,OR=3.880)、初次性生活年龄20岁(P=0.018,OR=3.127)、性伴数≥2个(P=0.021,OR=2.595)、妊娠次数≥2(P=0.030,OR=2.303)是HPV合并BV的独立影响因素。结论年龄大、初次性生活年龄小、性伴侣个数多、妊娠次数多为HPV合并BV的独立危险因素,临床中应做好知识普及工作,预防HPV合并BV的发生。

The influencing factors of BV combined with HPV infection

Abstract: Objective To analyze the influencing factors of bacterial vaginosis (BV) complicated with human papillomavirus (HPV) infection, so as to provide reference for the prevention of BV complicated with HPV infection. Methods Women admitted to the first affiliated hospital of tianjin university of traditional Chinese medicine from February 2017 to December 2017 who met the exclusion criteria were collected. The observation group was patients with HPV complicated with BV infection, and the control group was healthy women. Results A total of 204 subjects were included, 78 in the observation group and 126 in the control group. In the observation group, the majority of HPV infections were monomorphic, with 46 cases accounting for 59.0%. In the observation group, the majority of high-risk type infections were 70 cases, accounting for 89.7%. Univariate regression analysis showed that age 40 years old (P=0.000, OR=3.795), age of first sexual life <20 years old (P=0.011, OR=2.914), number of sexual partners 2 (P=0.036, OR=2.005), number of sexual life <2 per week (P=0.029, OR=1.927), and number of pregnancies 2 (P=0.000, OR=2.920) were the influential factors leading to HPV complicated BV. Multivariate unconditional logistic regression analysis showed that age 40 years old (P=0.001, OR=3.880), age of first sexual life <20 years old (P=0.018, OR=3.127), number of sexual partners 2 (P=0.021, OR=2.595), number of pregnancies 2 (P=0.030, OR=2.303) were independent influencing factors of HPV complicated BV. Conclusion Older age, earlier age of first sexual life, more number of sexual partners and more number of pregnancies are independent risk factors for HPV combined BV. In clinical practice, knowledge popularization should be done to prevent the occurrence of HPV combined BV.