268例吸毒女性人乳头瘤病毒感染情况调查及相关高危因素的分析

目的 调查268例吸毒女性人乳头瘤病毒感染情况并分析其相关高危因素。方法 选取我院2016年1月—2018年1月收入的268例吸毒女性作为研究对象，根据是否感染人乳头瘤病毒分为感染组70例及未感染组198例，比较两组吸毒女性基本资料，运用Logistic回归分析模型对具有统计学意义的因素进行分析，总结相关高危因素。结果 268例吸毒女性中人乳头瘤病毒感染者70例，感染率为26.12%且以高危型为主；两组吸毒女性基本资料中除年龄、受教育程度、肿瘤家族病史、盆腔炎病史无明显差异外，其他因素均有统计学意义（P＜0.05）。Logistic回归分析结果显示，免疫功能低下、初次性行为年龄过早（＜18周岁）、多个性伴侣（≥3个）、危险性行为、性伴侣吸毒、长期吸毒（≥3年）为女性吸毒人群人乳头瘤病毒感染的高危因素（OR=4.420、4.551、4.778、4.569、5.110、5.475，Ps＜0.05）。结论 女性吸毒人群人乳头瘤病毒感染率较高且以高危型为主，Logistic回归分析证实，吸毒女性中存在多种高危因素，应该及早针对高危因素采取干预措施。

Investigation on human papillomavirus infection in 268 female drug addicts and analysis of related high-risk factors

Objective To investigate the status of human papillomavirus infection among 268 female drug addicts and analyze their related high-risk factors．Methods 268 female drug addicts from January 2016 to January 2018 were selected as the subjects and divided into infection group（70 cases）or noninfection group（198 cases）．The basic information of the drug addicts was compared．Logistic regression analysis model was used to analyze statistically significant factors，and relevant high-risk factors were summarized．Results Among the 268 female drug addicts，70 were infected with human papillomavirus； the infection rate was 26.12% and the predominant HPV was high-risk type．There were no significant differences in the basic data of drug addicts between the two groups，including age，education level，tumor family history and history of pelvic inflammatory disease，but in the other factors（Ps<0.05）．Logistic regression analysis suggested that the immune dysfunction，premature age at first sexual intercourse（<18 years old），multiple sexual partners（≥3），risky sexual behavior，sexual partners being drug addicts and long-term drug use（≥3 years）were high-risk factors of human papillomavirus infection among female drug users（OR=4.420，4.551，4.778，4.569，5.110，5.475；Ps<0.05）．Conclusion The infection rate of human papillomavirus in female drug addicts is high and the predominant HPV is high-risk type．Logistic regression analysis confirms that there are many high-risk factors in female drug addicts．Intervention measures against high-risk factors should be taken as early as possible．