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Variant Plasmodium ovale isolated from a patient infected in Ghana
Authors:Tordrup David  Virenfeldt Jakob  Andersen Felicie F  Petersen Eskild
Affiliation:Department of Infectious Diseases, Institute of Clinical Medicine, Aarhus University Hospital-Skejby, Aarhus N., Denmark.
Abstract:Recent data have found that Plasmodium ovale can be separated in two distinct species: classic and variant P. ovale based on multilocus typing of different genes. This study presents a P. ovale isolate from a patient infected in Ghana together with an analysis of the small subunit RNA, cytochrome b, cytochrome c oxidase I, cysteine protease and lactate dehydrogenase genes, which show that the sample is a variant P. ovale and identical or highly similar to variant P. ovale isolated from humans in South-East Asia and Africa, and from a chimpanzee in Cameroon. The split between the variant and classic P. ovale is estimated to have occurred 1.7 million years ago.
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