Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes |
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Authors: | Mehrmohammadi Mohammad Oh Junghwan Mallidi Srivalleesha Emelianov Stanislav Y |
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Institution: | Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA. |
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Abstract: | Nano-sized particles are widely regarded as a tool to study biologic events at the cellular and molecular levels. However, only some imaging modalities can visualize interaction between nanoparticles and living cells. We present a new technique, pulsed magneto-motive ultrasound imaging, which is capable of in vivo imaging of magnetic nanoparticles in real time and at sufficient depth. In pulsed magneto-motive ultrasound imaging, an external high-strength pulsed magnetic field is applied to induce the motion within the magnetically labeled tissue and ultrasound is used to detect the induced internal tissue motion. Our experiments demonstrated a sufficient contrast between normal and iron-laden cells labeled with ultrasmall magnetic nanoparticles. Therefore, pulsed magneto-motive ultrasound imaging could become an imaging tool capable of detecting magnetic nanoparticles and characterizing the cellular and molecular composition of deep-lying structures. |
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