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Cap-assisted internal initiation of translation of histone H4
Authors:Martin Franck  Barends Sharief  Jaeger Sophie  Schaeffer Laure  Prongidi-Fix Lydia  Eriani Gilbert
Institution:Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg CEDEX, France.
Abstract:
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  • Highlights? Two structural elements of histone H4 mRNA drive translation initiation ? Ribosome is tethered by an eIF4E-binding site located in the coding region ? A RNA three-way helix junction element positions ribosome on the start codon ? The m7G cap-binding pocket formed by the mRNA controls histone translation
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