Spatial distribution of human liver aldehyde dehydrogenase isoenzymes |
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Authors: | I Piotr Maly Valérie Crotet D Sasse |
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Institution: | (1) Institute of Anatomy, University of Basel, Pestalozzistrasse 20, CH-4056 Basel, Switzerland e-mail: sassed@ubaclu.unibas.ch Tel.: +41-61-2673921, Fax: +41-61-2673959, CH |
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Abstract: | To elucidate the pattern of lesions in the liver parenchyma after ethanol ingestion, the quantitative distribution profiles
of both the cytosolic and the mitochondrial aldehyde dehydrogenase isoenzyme activities were determined by the use of ultrathin-layer
electrophoresis. It was found that in human liver parenchyma, both isoforms of aldehyde dehydrogenase are almost homogeneously
represented in the liver acinus. These quantitative data are supported by the results of an improved histochemical technique.
Moreover, sex differences were not detected either in activity or in the distribution pattern. Consequently, it can be assumed
that it is not the activity of total aldehyde dehydrogenase or its isoforms which is responsible for the higher susceptibility
of the perivenous zone to alcohol-dependent damage.
Accepted: 11 March 1999 |
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