Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines |
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| Authors: | Robert J. Majeska Sevgi B. Rodan Gideon A. Rodan |
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| Affiliation: | Department of Oral Biology, University of Connecticut Health Center, Farmington, CT 06032, USA |
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| Abstract: | Clonal cell lines possessing parathyroid hormone-stimulated adenylate cyclase were established from a rat osteosarcoma. These lines have retained undiminished hormone responsiveness through more than 5 months in continuous culture. Both the extent stimulation and hormone sensitivity were similar to those found in freshly excised tumor and embryonic bone. |
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