A possible mosaic form of delayed centromere separation and aneuploidy |
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| Authors: | Károly Méhes György Kosztolányi |
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| Affiliation: | (1) Department of Paediatrics, University Medical School of Pécs, József Attila u. 7, H-7623 Pécs, Hungary |
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| Abstract: | Summary On average, a  normal centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of delayed separation in the parent may account for trisomy in the offspring. |
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