GRP94, an ER chaperone with protein and peptide binding properties |
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Authors: | Argon Y Simen B B |
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Institution: | Department of Pathology, University of Chicago, IL 60637, USA. |
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Abstract: | GRP94 is the ER representative of the HSP90 family of stress-induced proteins. It binds to a limited number of proteins in the secretory pathway, apparently by recognizing advanced folding intermediates or incompletely assembled proteins, GRP94 also binds peptides and can act as a tumor vaccine, delivering the peptides for presentation to T lymphocytes. Here, we review the current data about GRP94 and propose a structural model that integrates the biochemical data and known functions of the protein. |
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