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Investigating the validity of current network analysis on static conglomerate networks by protein network stratification |
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| Authors: | Minlu Zhang " target="_blank">Long J Lu |
| Institution: | (1) Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA;(2) Department of Computer Science, University of Cincinnati, 2600 Clifton Avenue, Cincinnati, Ohio 45221, USA;(3) Department of Biomedical Engineering, University of Cincinnati, 2600 Clifton Avenue, Cincinnati, Ohio 45221, USA;(4) Department of Environmental Health, University of Cincinnati, 2600 Clifton Avenue, Cincinnati, Ohio 45221, USA |
| Abstract: | BackgroundA molecular network perspective forms the foundation of systems biology. A common practice in analyzing protein-protein interaction (PPI) networks is to perform network analysis on a conglomerate network that is an assembly of all available binary interactions in a given organism from diverse data sources. Recent studies on network dynamics suggested that this approach might have ignored the dynamic nature of context-dependent molecular systems. |
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