| 漆酶空间结构、反应机理及应用 |
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| 引用本文： | 葛宏华,武赟,肖亚中. 漆酶空间结构、反应机理及应用[J]. 生物工程学报, 2011, 27(2): 156-163 |
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| 作者姓名： | 葛宏华 武赟 肖亚中 |
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| 作者单位： | 安徽大学现代实验技术中心&生命科学学院,合肥,230039 |
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| 基金项目： | 安徽省教育厅自然基金重点项目 (No. KJ2008A127)，安徽大学博士启动基金项目 (No. 02203105) 资助。 |
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| 摘 要： | 漆酶 (EC 1.10.3.2) 属于多铜氧化酶家族，可以催化氧化酚类和芳香类化合物，利用自由基反应机理完成4个电子的转移，并将分子氧还原成水。漆酶具有非常保守的拓扑学结构，结合作者自身工作实践，对漆酶结构与功能的最新研究进展进行综述，其中对漆酶的三维结构、活性中心、催化机理研究和最新的应用进展作重点阐述。
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| 关 键 词： | 多铜氧化酶，漆酶结构，三核中心 |
| 收稿时间： | 2010-05-11 |
| 修稿时间： | 2010-06-25 |
Structure, catalytic mechanism and applications of laccases: a review |
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| Honghua Ge,Yun Wu and Yazhong Xiao. Structure, catalytic mechanism and applications of laccases: a review[J]. Chinese journal of biotechnology, 2011, 27(2): 156-163 |
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| Authors: | Honghua Ge Yun Wu Yazhong Xiao |
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| Affiliation: | Modern Experiment Technology Center & School of Life Sciences, Anhui University, Hefei 230039, China;Modern Experiment Technology Center & School of Life Sciences, Anhui University, Hefei 230039, China;Modern Experiment Technology Center & School of Life Sciences, Anhui University, Hefei 230039, China |
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| Abstract: | Laccases (benzenediol: oxygen oxidoreductases; EC 1.10.3.2) are copper-containing polyphenol oxidases that can oxidize a wide range of aromatic compounds, concomitantly with the transfer of four electrons and the reduction of molecular oxygen to water. The progress on the research of laccases structure and function is reviewed. Their three-dimensional structures and catalytic mechanism, as well as their applications in different fields are emphasized. |
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| Keywords: | multicopper oxidases laccase structure trinuclear cluster |
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