Electron microscope observations of radiation-induced Hela giant cells

Summary An electron microscope study of X-ray produced giant Hela cells is described. The results extend earlier light microscope observations to the sub-microscopic region where clear differences from normal structures are apparent. Of particular interest are intra nuclear inclusions, nucleolar fragments, membrane abnormalities and possible mitochondrial changes.This investigation was supported in part by the U. S. Atomic Energy Commission and in part by a predoctoral fellowship CF 8984 from the National Cancer Institute, Public Health Service.