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Reactivity of a new class of P450 enzyme models |
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| Authors: | Meyer Dominik Leifels Tycho Sbaragli Laura Woggon Wolf-D |
| Institution: | Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland. |
| Abstract: | P450 enzyme models carrying a SO3(-) ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated. |
| Keywords: | Enzyme models P450 Heme-thiolate proteins Iron porphyrins Catalysis Epoxidation Hydroxylation N-Dealkylation Diol cleavage |
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