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Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound |
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| Authors: | Tomassi Cyrille Nguyen Van Nhien Albert Marco-Contelles José Balzarini Jan Pannecouque Christophe De Clercq Erik Soriano Elena Postel Denis |
| Affiliation: | Laboratoire des Glucides (UMR6219), Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France. |
| Abstract: | The synthesis and the biological evaluation of the anti-HIV-1 activity of TSAO-Boc(3)T (8) are described. The computational analysis showed that the N-3 Boc group promotes new interactions in the binding site of the enzyme leading to a good inhibitory activity. |
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