Chemical structure of posttranslational modification with a farnesyl group on tryptophan |
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Authors: | Okada Masahiro Yamaguchi Hisao Sato Isao Tsuji Fumitada Dubnau David Sakagami Youji |
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Institution: | Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan. |
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Abstract: | Bacillus subtilis and related bacilli produce a posttranslationally modified oligopeptide, the ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX(RO-C-2) pheromone from strain RO-C-2 must be modified with a farnesyl group on the Trp residue, but the precise structure is not known. Here we report the precise nature of posttranslational farnesylation of ComX(RO-C-2) pheromone on the Trp residue, resulting in the formation of a tricyclic structure. The ComX(168) pheromone, produced by the standard laboratory strain used in the study of B. subtilis, is also posttranslationally farnesylated according to phylogenetic resemblance. |
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