Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416 |
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| Authors: | Pandit Bulbul Sun Yanjun Chen Ping Sackett Dan L Hu Zhigen Rich Wendy Li Chenglong Lewis Andrew Schaefer Kevin Li Pui-Kai |
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| Affiliation: | Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA. |
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| Abstract: | A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported. |
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