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Relationships between %Hb F or %G gamma and the haplotypes in the beta-globin gene cluster in the normal adult Japanese and Korean populations.
Authors:K Shimizu  K S Park  S Harihara  Y Enoki
Institution:Department of Morphology, Institute for Developmental Research Aichi Prefectural Colony, Japan.
Abstract:Haplotypes or subhaplotypes in the beta-globin gene cluster were examined in 31 normal Japanese and 21 Korean families. Major haplotypes were VII, V, and I, which shared a common subhaplotype +----], and occurred in 70% of the Japanese and 68% of the Koreans. Three haploypes which shared a common subhaplotype -+-++], bearing the XmnI site 5' to the G gamma-globin gene, occurred in 13% of the Japanese and 7.3% of the Koreans. One subhaplotype -++-+], which is closely linked to the A gamma T-globin gene, had an incidence of 6.6% in the Japanese and 20% in the Koreans. Rare subhaplotypes ---++], and - +] which has been observed mainly in Melanesians and Polynesians, and a very rare subhaplotype -----] were observed. The present study suggests that high or low G gamma-globin chain production is closely related to subhaplotypes -+-++] and +----], respectively, among the normal adult population.
Keywords:
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