| Abstract: | A study was made of the effects of cAMP, db-cGMP and db-cAMP on the mitotic activity of the cells of the tooth anlage and alveolar bone in tissue culture of mouse embryo aged 15 days. The data indicate that db-cGMP and db-cAMP at concentrations 10(-6) M and 10(-8) M do not have any essential effect on the mitotic activity of the cells of the tooth anlage whereas cAMP inhibits the mitotic activity in these cells as compared with control. A definite relationship was established between the character of differentiation of the osseous and dental tissues in tissue culture and the concentration of cyclic nucleotides. db-cAMP, db-cGMP and cAMP raise the mitotic activity of the osteogenic cells, inhibit resorption of the alveolar bone, and stimulate formation of a new osseous tissue. |
