Formation of retinoic acid from retinol in the rat |
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| Authors: | R J Emerick Maija Zile and H F DeLuca |
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| Institution: | Department of Biochemistry, University of Wisconsin, Madison, Wis. 53706, U.S.A. |
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| Abstract: | 1. The formation in vivo of retinoic acid from microgram quantities of intrajugularly administered 15-(14)C]retinol was demonstrated in the rat. 2. Endogenously formed retinoic acid (about 0.1mug./rat) was found in liver, and to a much smaller extent in intestine, 12hr. after retinol administration. 3. Excretion of some of the endogenously formed retinoic acid occurred in the bile of bile-duct-cannulated rats. 4. Excretion of unaltered retinoic acid in the urine of intact rats did not occur even after the intrajugular administration of preformed retinoic acid. |
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