Bombesin-like immunoreactivity in the nervous system of hydra |
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| Authors: | C J P Grimmelikhuijzen G J Dockray N Yanaihara |
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| Institution: | (1) Abteilung Biophysik, Zoologisches Institut der Universität, Heidelberg, Federal Republic of Germany;(2) Department of Physiology, University of Liverpool, Liverpool, England;(3) Department of Bioorganic Chemistry, Shizuoka College of Medicine, Shizuoka-shi, Japan;(4) Max-Plank-Institut für medizinische Forschung, Jahnstraße 29, D-6900 Heidelberg, Federal Republic of Germany |
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| Abstract: | Summary With immunocytochemical methods, nerve cells have been detected in Hydra attenuata containing bombesin-like immunoreactivity. These nerve cells are located in the ectoderm of all body regions of the animal and are especially abundant in basal disk and tentacles. Radioimmunoassay of extracts of hydra demonstrated at least 0.2 pmol/g wet weight of bombesinlike immunoreactivity. The immunoreactive material elutes from Sephadex G-50 in a similar position to synthetic bombesin. The data show that bombesin-like peptides are among the phylogenetically oldest neuropeptides found so far. |
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