Development and strategies of cell-culture technology for influenza vaccine |
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Authors: | Shao-Zhen Feng Pei-Rong Jiao Wen-Bao Qi Hui-Ying Fan Ming Liao |
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Institution: | (1) Laboratory of Avian Medicine, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; |
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Abstract: | Influenza is a pandemic contagious disease and causes human deaths and huge economic destruction of poultry in the world.
In order to control and prevent influenza, mainly type A, influenza vaccine for human and poultry were available since the
1940s and 1920s, respectively. In the development of vaccine production, influenza viruses were cultured originally from chicken
embryos to anchorage-dependent cell lines, such as MDCK and Vero. The anchorage-independent lines have also been used to produce
influenza virus, such as PER.C6 and engineering modified MDCK and Vero. During the process of influenza vaccine production,
the common problem faced by all producers is how to improve the titer of influenza virus. This paper focuses on the developments
of cell culture for influenza virus vaccine production, limitations of cell culture, and relative strategies for improvement
virus yields in cell-culture systems. |
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