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Adenyl cyclase in human hair follicles: its inhibition by dihydrotestosterone
Authors:K Adachi  M Kano
Affiliation:1. Department ‬of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;2. Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24, 71-460 Szczecin, Poland;3. Department of Physiology, Pomeranian Medical University, Al. Powstańców Wlkp. 72, 70-111 Szczecin, Poland;4. Department of Pharmacology and Pharmacodynamic, Medical University, Chodźki 4a, 20-093 Lublin, Poland;5. Department of Conservative Dentistry and Endodontics, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland;1. Department of Psychology, Umeå University, Sweden;2. Department of Chemistry, Umeå University, Sweden;3. Umeå School of Business and Economics, Department of Statistics, Umeå University, Sweden;4. Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden;1. Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark;2. Department of Neuroscience, University of Copenhagen, Copenhagen, Denmark;1. Department of Hypertensiology, Angiology and Internal Medicine, Poznań University of Medical Sciences, Długa 1/2 Str., 61-848 Poznań, Poland;2. Department of Toxicology, Poznań University of Medical Sciences, Dojazd 30 Str., 60-631 Poznań, Poland;1. Department of Oncology, Georgetown University, United States;2. Department Pediatrics, Georgetown University, United States
Abstract:Particulate fractions obtained from human scalp hair follicles contained adenyl cyclase activity which was activated by estrone and inhibited by dihydrotestosterone (5α-androstan-17β-ol-3-one)1. The marked inhibition of this enzyme activity by dihydrotestosterone but not by testosterone suggests that the former is the tissue-active androgen. We then speculate that the initial step in the development of pattern baldness is controlled by the intracellular level of dihydrotestosterone rather than testosterone as mediated by adenyl cyclase (and cyclic AMP).
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