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Evidences of lateral gene transfer between archaea and pathogenic bacteria
Authors:Habib Bokhari  Maryam Anwar  Hasan Bilal Mirza  Patrick Martin Gillevet
Institution:1Department of Biosciences, COMSATS Institute of Information Technology, Chakshahzad Campus, Park road Islamabad, Pakistan;2Centre for Advanced Studies in Telecommunication (CAST), COMSATS Institute of Information Technology, Chakshahzad Campus, Park road Islamabad, Pakistan;;3Department of Environmental Sciences and Policy, George Mason University, Manassas, Virginia, USA
Abstract:Acquisition of new genetic material through horizontal gene transfer has been shown to be an important feature in the evolution of many pathogenic bacteria. Changes in the genetic repertoire, occurring through gene acquisition and deletion, are the major events underlying the emergence and evolution of bacterial pathogens. However, horizontal gene transfer across the domains i.e. archaea and bacteria is not so common. In this context, we explore events of horizontal gene transfer between archaea and bacteria. In order to determine whether the acquisition of archaeal genes by lateral gene transfer is an important feature in the evolutionary history of the pathogenic bacteria, we have developed a scheme of stepwise eliminations that identifies archaeal-like genes in various bacterial genomes. We report the presence of 9 genes of archaeal origin in the genomes of various bacteria, a subset of which is also unique to the pathogenic members and are not found in respective non-pathogenic counterparts. We believe that these genes, having been retained in the respective genomes through selective advantage, have key functions in the organism’s biology and may play a role in pathogenesis.
Keywords:Phylogenetics  Lateral gene transfer  Pathogenesis
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