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Genome sequences of Mycoplasma alligatoris A21JP2T and Mycoplasma crocodyli MP145T |
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| Authors: | Brown D R Farmerie W G May M Benders G A Durkin A S Hlavinka K Hostetler J Jackson J Johnson J Miller R H Paralanov V Radune D Szczypinski B Glass J I |
| Affiliation: | 1Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, Florida 32608;2Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida 32610;3Department of Biological Sciences, Towson University, Towson, Maryland 21252;4The J. Craig Venter Institute, Rockville, Maryland 20850 |
| Abstract: | Mycoplasma alligatoris and Mycoplasma crocodyli are closely related siblings, one being highly virulent and the other relatively attenuated. We compared their genomes to better understand the mechanisms and origins of M. alligatoris' remarkable virulence amid a clade of harmless or much less virulent species. Although its chromosome was refractory to closure, M. alligatoris differed most notably by its complement of sialidases and other genes of the N-acetylneuraminate scavenging and catabolism pathway. |
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