Annotation of hypothetical proteins orthologous in Pongo abelii and Sus scrofa

A hypothetical protein is predicted to be expressed from an open reading frame without known experimental evidence of translation. They constitute a substantialfraction of proteomes. Domain extraction from these hypothetical sequences helps to search for protein coding genes for protein structural and functionalannotation. We describe the analysis of prediction data in a sequence dataset of hypothetical protein orthologs of Pongo abelii (orangutan) and Sus scrofa (pig). Itshould be noted that these orangutan-pig orthologs are also non-homologous to human proteins. These predicted data find application in the genome wideannotation of proteins in poorly understood genomes.

Abbreviations

PDB - Protein Data Bank, DEG - Database of Essential Genes, CDD - Conserved Domain Database, IUCN - International Union for Conservation of Nature.