Structural polypeptides of primate derived type C RNA tumor viruses |
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Authors: | P Roy-Burman B K Pal M B Gardner |
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Institution: | Departments of Pathology and Biochemistry University of Southern California School of Medicine Los Angeles, California 90033 USA;Department of Pediatrics, University of Southern California School of Medicine, Childrens Hospital of Los Angeles Los Angeles, California 90027 USA |
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Abstract: | Proteins of gibbon ape lymphosarcoma virus (GaLV) and woolly monkey sarcoma virus, type 1, together with its associated virus () were analyzed by guanidine-agarose chromatography and the separation patterns were compared with those of mouse and feline type C viruses. GaLV contained five major proteins, including two glycoproteins, whereas lower mammalian viruses contained six major proteins, including two glycoproteins. The molecular weights of the five GaLV proteins closely resembled the molecular weights of the five equivalent lower mammalian viral proteins. showed a separation pattern similar to GaLV except it contained a low but detectable amount of an additional glycoprotein. Both GaLV and were deficient in a protein of molecular weight about 15,000 daltons which is found in all known type C viruses of avian, reptilian and lower mammalian species. |
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