Preparation and Enantioselectivity Binding Studies of a New Chiral Cobalt(II)porphyrin‐Tröger's Base Conjugate |
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| Authors: | Ameneh Tatar Martin Valík Jana Novotná Martin Havlík Bohumil Dolenský Vladimír Král Marie Urbanová |
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| Institution: | 1. Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic;2. Department of Physics and Measurements, Institute of Chemical Technology Prague, Praha, Czech Republic |
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| Abstract: | A new biscobalt(II)porphyrin]‐Tröger's base conjugate was studied as a potential receptor for methyl esters of several amino acids. The conjugate was prepared as racemate, and then resolved via preparative high‐performance liquid chromatography (HPLC) on a chiral column. The high affinity to lysine, histidine, and proline methyl esters was found by complexation studies followed by UV‐Vis spectroscopy. The studies of pure enantiomers, followed by UV‐Vis and electronic circular dichroism spectroscopy, revealed the highest enantioselectivity for lysine methyl ester. Chirality 26:361–367, 2014. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | Trö ger's base conjugate enantioselectivity chiral receptors |
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