首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Anion Effect on the Binary and Ternary Phase Diagrams of Chiral Medetomidine Salts and Conglomerate Crystal Formation
Authors:Ebrahim Choobdari  Hossein Fakhraian  Mohammad Hassan Peyrovi
Institution:1. Department of Chemistry, Shahid Beheshti University, Tehran, Iran;2. Department of Chemistry, Imam Hossein University, Tehran, Iran
Abstract:The binary phase diagrams of hydrogen halides salts of medetomidine (Med.HX, X:Br,I) and hydrogen oxalate salt of medetomidine (Med.Ox) were determined based on thermogravimetric/differential thermal analysis (TGA/DTA) and their crystal structure behavior was confirmed by comparison of the X‐ray diffractometry and FT‐IR spectroscopy of the racemate and pure enantiomer. All hydrogen halide salts presented racemic compound behavior. Heat of fusion of halides salt of (rac)‐medetomidine decreased with ionic radius increase. Eutectic points for Med.HCl (previously reported), Med.HBr, and Med.HI rest were unchanged approximately. The solubility of different enantiomeric mixtures of Med.HBr and Med.HI were measured at 10, 20, and 30°C in 2‐propanol showing a solubility increase with ionic radius. A binary phase diagram of Med.Ox shows a racemic conglomerate behavior. The solubility of enantiomeric mixtures of Med.Ox were measured at 10, 20, 30, and 40°C. The ternary phase diagram of Med.Ox in ethanol conforms to a conglomerate crystal forming system, favoring its enantiomeric purification by preferential crystallization. Chirality 26:183–188, 2014. © 2014 Wiley Periodicals, Inc.
Keywords:medetomidine  enantiomer  conglomerate  racemic compound  phase diagram  X‐ray diffractometry  thermogravimetric analysis  differential thermal analysis  chiral resolution  preferential crystallization
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号