Determination of the Absolute Stereochemistry of Two New Aristophyllene Sesquiterpenes: A Combined Theoretical and Experimental Investigation |
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| Authors: | Rui‐Bo Wu Zhong‐Bin Cheng Qing‐Hua Han Ting‐Ting Lin Jing‐Wei Zhou Gui‐Hua Tang Sheng Yin |
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| Affiliation: | School of Pharmaceutical Sciences, Sun Yat‐sen University, Guangzhou, Guangdong, People's Republic of China |
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| Abstract: | Aristoyunnolins G ( 1 ) and H ( 2 ), two new diastereoisomeric sesquiterpenes featuring a rare aristophyllene skeleton, were isolated from the traditional Chinese medicine Aristolochia yunnanensis. Their absolute stereochemistry involving three chiral centers was determined by combined chemical, spectral, and Density Functional Theory (DFT) calculation methods. Chirality 26:189–193, 2014. © 2014 Wiley Periodicals, Inc. |
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| Keywords: | aristophyllene sesquiterpenes absolute configuration ECD DFT |
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