| 肿瘤坏死因子相关凋亡诱导配体研究进展 |
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| 引用本文： | 张伟,刘志敏. 肿瘤坏死因子相关凋亡诱导配体研究进展[J]. 生物技术通讯, 2003, 14(2): 138-140 |
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| 作者姓名： | 张伟 刘志敏 |
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| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | TRAIL(又称为Apo2L)是TNF超家族的新成员。它可以选择性诱导肿瘤细胞的凋亡，而对正常细胞无凋亡作用本介绍了TRAIL的结构和功能、凋亡途径、肝毒性研究及应用前景。TRAIL很可能成为新一代的抗肿瘤制剂。
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| 关 键 词： | 肿瘤坏死因子 细胞凋亡 TRAIL 凋亡诱导配体 结构 功能 肝毒性 抗肿瘤制剂 TNF超家族 |
| 文章编号： | 1009-0002(2003)02-0138-03 |
| 修稿时间： | 2002-10-29 |
Advance in TNF-related apoptosis-inducing ligand |
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| ZHANG Wei,LIU Zhi-Min. Advance in TNF-related apoptosis-inducing ligand[J]. Letters in Biotechnology, 2003, 14(2): 138-140 |
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| Authors: | ZHANG Wei LIU Zhi-Min |
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| Abstract: | TRAIL(TNF-related apoptosis-inducing ligand),which calls also Apo-2L,is a new member of TNF su-perfamily.It could selectively inducing the apoptosis of tumor cells,but not the normal cell.This review introduces reseach progress on TRAIL from several aspects:structure and function,the pathway of inducing apoptosis,the re-seach of liver toxin,and its prospect. |
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| Keywords: | TNF-related apoptosis-inducing ligand receptor apoptosis liver toxicity |
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