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A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance
Authors:Luke S Tain  Robert Sehlke  Chirag Jain  Manopriya Chokkalingam  Nagarjuna Nagaraj  Paul Essers  Mark Rassner  Sebastian Grönke  Jenny Froelich  Christoph Dieterich  Matthias Mann  Nazif Alic  Andreas Beyer  Linda Partridge
Affiliation:1. Max‐Planck Institute for Biology of Ageing, Cologne, Germany;2. CECAD Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Cologne, Germany;3. Department of Proteomics and Signal Transduction, Max‐Planck‐Institute of Biochemistry, Martinsried, Germany;4. Section 5. of Bioinformatics and Systems Cardiology, Department of Internal Medicine III and Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Heidelberg, Germany;6. DZHK (German Centre for Cardiovascular Research), Partner site Heidelberg/Mannheim, Heidelberg, Germany;7. Institute of Healthy Ageing, and GEE, UCL, London, UK;8. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Abstract:
Keywords:ageing  insulin/IGF  mitochondria  proteasome  proteome
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