Thyroid-state influence on protein-expression profile of rat skeletal muscle |
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| Authors: | Silvestri Elena Burrone Lavinia de Lange Pieter Lombardi Assunta Farina Paola Chambery Angela Parente Augusto Lanni Antonia Goglia Fernando Moreno Maria |
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| Institution: | Dipartimento di Scienze Biologiche ed Ambientali, Università degli Studi del Sannio, Via Port'Arsa 11, 82100 Benevento, Italy. |
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| Abstract: | We analyzed the whole-cell protein content of gastrocnemius muscles from rats in different thyroid states. Twenty differentially expressed proteins were unambiguously identified. They were involved in substrates and energy metabolism, stress response, cell structure, and gene expression. This study represents the first systematic identification of thyroid state-induced changes in the skeletal muscle protein-expression profile and reveals new cellular pathways as targets for thyroid hormone action. |
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