Protein kinase mediated phosphorylation of the rat liver plasma membrane |
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| Authors: | L Shlatz G V Marinetti |
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| Affiliation: | 1. Department of Civil and Environmental Engineering, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA;2. School of Freshwater Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA;3. Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland, USA;1. Division of Nephrology, Stanford University School of Medicine, Palo Alto, California, USA;2. Division of Nephrology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA;3. Division of Nephrology, Columbia University, New York, New York, USA;4. Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada;5. Division of Nephrology, Department of Pediatrics, LSU Health and Children’s Hospital, New Orleans, Louisiana, USA;6. UNC Kidney Center, Division of Nephrology and Hypertension, University of North Carolina, Chapel Hill, North Carolina, USA;7. Center for Pediatric Nephrology, Cleveland Clinic Children’s, Cleveland, Ohio, USA;8. Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA;9. Children’s Mercy Hospital, Kansas City, Missouri, USA;10. Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota Masonic Children’s Hospital, Minneapolis, Minnesota, USA;11. Division of Pediatric Kidney Services and Hypertension, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon, USA;12. Division of Nephrology, Department of Pediatrics, Children’s Hospital of Philadelphia, Wynnewood, Pennsylvania, USA;13. JW Riley Hospital for Children, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA;14. Division of Nephrology, Department of Pediatrics, New York University School of Medicine, New York, New York, USA;15. Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA;16. Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA;17. Division of Pediatric Nephrology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA;18. Division of Kidney, Urologic, and Hematologic Diseases, The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA;19. Center for Translational Research, Children’s National Health System, Washington, DC, USA;20. Division of Nephrology, Maisonneuve-Rosemont Hospital, Department of Medicine, University of Montreal, Montreal, Quebec, Canada |
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| Abstract: | Partially purified protein kinase from rat liver has been found to phosphorylate the isolated rat liver plasma membrane. The level of phosphorylation is increased two fold by 10−6M cyclic AMP. Glucagon and epinephrine at 10−6M to 10−7 M also stimulated the kinase dependent phosphorylation of the membrane, glucagon being more effective than epinephrine. The phosphorylated membrane has been found to bind more Ca++ than the control membrane. These studies suggest a new role for certain hormones. These hormones may influence the structure and function of the membrane, in particular the permeability of the membrane, by controlling the degree of phosphorylation and bound calcium. |
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