SNP‐based genetic characterization of the Tulane National Primate Research Center's conventional and specific pathogen‐free rhesus macaque (Macaca mulatta) populations |
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| Authors: | Sree Kanthaswamy Jillian Ng Robert F. Oldt Kathrine Phillippi‐Falkenstein H. Michael Kubisch |
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| Affiliation: | 1. School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, USA;2. Julie Ann Wrigley Global Institute of Sustainability, Arizona State University, Tempe, AZ, USA;3. Evolutionary Biology PhD program, School of Life Sciences, Arizona State University, Tempe, AZ, USA;4. California National Primate Research Center, University of California, Davis, CA, USA;5. Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA |
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| Abstract: | Background The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States. Methods SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. Results Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation. Conclusions The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events. |
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| Keywords: | genetic composition genetic management genetic structure population genetics single nucleotide polymorphisms |
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