The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rats |
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| Authors: | Susan Holt and David A. York |
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| Affiliation: | Department of Nutrition, School of Biochemical and Physiological Sciences, University of Southampton, Southampton SO9 5NH, U.K. |
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| Abstract: | GDP binding to brown-adipose-tissue mitochondria of young obese Zucker rats (fa/fa) was significantly lower than in lean control rats, as a result of a decrease in the number of binding sites. Adrenalectomy of fa/fa rats restored GDP binding to control values. Corticosterone replacement suppressed GDP binding in adrenalectomized obese rats. |
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