Airway regeneration: the role of the Clara cell secretory protein and the cells that express it |
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| Authors: | Amy P. Wong Armand Keating Thomas K. Waddell |
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| Affiliation: | 1. Department of Pharmacy and Pharmacology, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa;2. Department of Pharmaceutical Sciences, University of KwaZulu Natal, Berea, Durban 4041, South Africa;3. Ophthalmology Division, Department of Neurosciences, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa |
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| Abstract: | Clara cell secretory protein (CCSP) is one of the most abundant proteins in the airway surface fluid, and has many putative functions. Recent advances in the field of stem cells and lung regeneration have identified potentially new roles of CCSP and CCSP-expressing cell populations in airway maintenance, repair and regeneration. This review focuses on the airway regenerative potential of CCSP and the cells that express this protein. The use of this protein or CCSP-expressing cells as an indication of biologic processes that contribute to lung injury or repair is highlighted. |
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