Thalamic bursts modulate cortical synchrony locally to switch between states of global functional connectivity in a cognitive task |
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| Authors: | Oscar Portoles Manuel Blesa Marieke van Vugt Ming Cao Jelmer P. Borst |
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| Affiliation: | 1. Bernoulli Institute for Mathematics, Computer Science and Artificial Intelligence, Faculty of Science and Engineering, University of Groningen, Groningen, The Netherlands;2. Engineering and Technology Institute Groningen, Faculty of Science and Engineering, University of Groningen, Groningen, The Netherlands;3. MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom; University College London, UNITED KINGDOM |
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| Abstract: | Performing a cognitive task requires going through a sequence of functionally diverse stages. Although it is typically assumed that these stages are characterized by distinct states of cortical synchrony that are triggered by sub-cortical events, little reported evidence supports this hypothesis. To test this hypothesis, we first identified cognitive stages in single-trial MEG data of an associative recognition task, showing with a novel method that each stage begins with local modulations of synchrony followed by a state of directed functional connectivity. Second, we developed the first whole-brain model that can simulate cortical synchrony throughout a task. The model suggests that the observed synchrony is caused by thalamocortical bursts at the onset of each stage, targeted at cortical synapses and interacting with the structural anatomical connectivity. These findings confirm that cognitive stages are defined by distinct states of cortical synchrony and explains the network-level mechanisms necessary for reaching stage-dependent synchrony states. |
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