Binding of benzo[a]pyrene to different chromatin domains following activation at the nuclear membrane |
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| Authors: | F. O. Obi M. A. Billett |
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| Affiliation: | (1) Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, NG7 2UH Nottingham, UK;(2) Present address: Department of Biochemistry, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria |
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| Abstract: | When isolated liver nuclei from methylchol-anthrene-treated rats are incubated with benzopyrene, covalent adducts are formed between DNA and the ultimate carcinogen, benzopyrene diol epoxide. Brief digestion with DNaseI, or micrococcal nuclease has been used to demonstrate that benzopyrene metabolites bind more readily to DNA in chromatin regions with a more open, active conformation than to inactive chromatin. |
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