Utilization of biocatalytic promiscuity for direct Mannich reaction |
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| Affiliation: | 1. Department of Biochemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, Thailand;2. Department of Biotechnology, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom, Thailand;3. School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley, Rayong, Thailand |
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| Abstract: | A lipase-catalyzed direct Mannich reaction of arylamines with aromatic aldehydes and ketones including cyclohexanone, butanone and 1-hydroxy-2-propanone was developed under EtOH/H2O system in a “one-pot” strategy. A series of experiments on the promiscuous activity of lipases were performed to optimize the biocatalytic process, and a wide scope of substrates was expanded with good yields. |
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