A generic method for assignment of reliability scores applied to solvent accessibility predictions |
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Authors: | Bent Petersen Thomas Nordahl Petersen Pernille Andersen Morten Nielsen Claus Lundegaard |
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Affiliation: | (1) Center for Biological Sequence Analysis – CBS, Department of Systems Biology, Kemitorvet 208, Technical University of Denmark – DTU, DK-2800 Lyngby, Denmark;(2) Centre for Medical Parasitology – CMP, CSS Building 22, University of Copenhagen, DK-1014 Copenhagen, Denmark |
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Abstract: | Background Estimation of the reliability of specific real value predictions is nontrivial and the efficacy of this is often questionable. It is important to know if you can trust a given prediction and therefore the best methods associate a prediction with a reliability score or index. For discrete qualitative predictions, the reliability is conventionally estimated as the difference between output scores of selected classes. Such an approach is not feasible for methods that predict a biological feature as a single real value rather than a classification. As a solution to this challenge, we have implemented a method that predicts the relative surface accessibility of an amino acid and simultaneously predicts the reliability for each prediction, in the form of a Z-score. |
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